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1432 CE: Mehmed II is born.
1437 CE: Mehmed II is appointed governor of Amasya.
1444 CE: Mehmed II inherits the throne after Sultan Murad II abdicates.
1444 CE: Murad II resumes defeats Crusader forces at the Battle of Varna.
1451 CE - 1481 CE: Mehmed II rules as the Sultan.
1451 CE: Mehmed II succeeds Murad as sultan following his death.
1452 CE: Construction of fortress Rumelihisari is complete.
1453 CE: Siege of Constantinople begins.
1453 CE: Ottoman Sultan Mehmed II sacks Constantinople.
1454 CE - 1459 CE: Ottoman campaigns in Serbia.
1456 CE: Ottoman forces besiege Trebizond.
1456 CE: Mehmed II is dealt his first major defeat at the Siege of Belgrade.
1461 CE: Ottoman forces under Sultan Mehmed II capture Trebizond, ending the Empire of Trebizond.
1461 CE: David Megas Komnenos, the last Emperor of Trebizond, is deposed by the Ottomans.
1463 CE - 1479 CE: The Ottomans fight a long war against the Venetians over their possessions in the Aegean.
1463 CE - 1470 CE: The Mosque of the Conqueror is constructed in Constantinople.
1465 CE: Mehmed II oversees construction of Topkapi Palace, the new seat of his empire.
1481 CE: Mehmed II falls ill during a military expedition and subsequently dies, leading to the succession of his eldest son Bayezid II to the throne.