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1251 CE - 1259 CE: Reign of Mongke Khan, ruler of the Mongol Empire.
1253 CE - 1260 CE: A Mongol army led by Hulegu invades Persia and the Middle East.
1256 CE: The Mongols defeat the Ismailis (aka the Assassins) in Persia.
1258 CE: The Mongols conquer the Abbasid Caliphate. During this campaign there is the infamous sacking of Baghdad and murder of the caliph.
1259 CE: The Mongols besiege and capture Aleppo in Syria.
1260 CE - 1264 CE: Kublai Khan fights a civil war with his brother Ariq Boke for control of the Mongol Empire.
1260 CE - 1265 CE: Hulegu rules the Ilkhanate.
1260 CE - 1335 CE: The Mongol Ilkhanate rules in Iran and neighbouring territories.
1262 CE: Golden Horde forces under Nogai defeat the Ilkhanate at the Battle of Terek.
1265 CE - 1282 CE: Abaqa rules the Ilkhanate.
1270 CE: Abaqa, ruler of the Ilkhanate, defeats Baraq, ruler of the Chagatai Khanate, at the battle of Herat.
1271 CE: The Ilkhanate signs a trade agreement with Venice.
1273 CE: Abaqa, ruler of the Ilkhanate, sacks the city of Bukhara in the Chagatai Khanate.
1277 CE: The Ilkhanate defeats a Mamluk army in Lesser Armenia.
1282 CE - 1284 CE: Ahmad Teguder rules the Ilkhanate.
1284 CE - 1291 CE: Arghun rules the Ilkhanate.
1288 CE: The Ilkhanate agrees a trade deal with Genoa.
1291 CE - 1295 CE: Gaikhatu rules the Ilkhanate.
1295 CE: Baidu rules the Ilkhanate.
1295 CE - 1304 CE: Ghazan rules the Ilkhanate.
1295 CE: Ghazan, ruler of the Ilkhanate, converts to Islam.
1299 CE: The Ilkhanate briefly captures Mamluk-controlled Aleppo and Damascus.
1303 CE: The Mamluks defeat an Ilkhanate army in Syria at Marj al-Suffar.
1304 CE - 1316 CE: Oljeitu rules the Ilkhanate.
1316 CE - 1335 CE: Abu Said rules the Ilkhanate.
1322 CE: The Ilkhanate and Mamluk Sultanate sign a peace treaty.
1335 CE: The Ilkhanate disintegrates into smaller states following dynastic disputes.